Inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution.
S. K. Marx, K. J. Mickolajczyk, J. M. Craig, C. A. Thomas, A. M. Pfeffer, S. J. Abell, J. D. Carrasco, M. C. Franzi, J. R. Huang, H. C. Kim, H. D. Brinkerhoff, T. M. Kapoor, J. H. Gundlach, A. H. Laszlo
This study uses nanopore tweezers to analyze SARS-CoV-2 helicase nsp13 motion and inhibition at single-nucleotide resolution, revealing kinetic mechanisms and inhibitor effects.
bioRxiv · Oct 7, 2022 · PreprintBiophysics