An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction
T. S. Sumida, M. R. Lincoln, L. He, Y. Park, M. Ota, H. A. Stillwell, G. A. Leissa, K. Fujio, A. Kulminski, C. B. Epstein, B. E. Bernstein, M. Kellis, D. A. Hafler
This study identifies a primate-specific PRDM1 isoform and its interaction with SGK1 as drivers of Treg dysfunction in autoimmune diseases.
bioRxiv · Dec 2, 2022 · PreprintImmunology