Y. Park

KMT2d regulates tooth enamel development

This study investigates the role of KMT2D in amelogenesis using a conditional knockout mouse model, revealing its critical role in enamel development and identifying direct target genes involved in ameloblast differentiation.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

Three-dimensional Label-Free Measurements of Adipocyte Differentiation and Lipid Droplet Dynamics

This study uses low-coherence holotomography to track adipocyte differentiation and lipid droplet dynamics over 42 days without labeling.

A "through-DNA" mechanism for metal uptake-vs.-efflux regulation

The paper reveals a through-DNA mechanism where ZntR influences Zur's DNA binding kinetics, enabling coordinated metal uptake and efflux regulation in E. coli.

Revealing 3D cancer tissue structures using holotomography and virtual hematoxylin and eosin staining via deep learning

This paper develops a 3D virtual H&E staining method using holotomography and deep learning for cancer tissues, validated on colon and gastric cancer samples.

Antibody-conjugating nanogel (Conjugel) with two immune checkpoint inhibitors for enhanced cancer immunotherapy

This study develops a nanogel-based system that delivers two immune checkpoint inhibitors, enhancing cancer immunotherapy efficacy and reducing toxicity compared to traditional methods.

Functional immune state classification of unlabeled live human monocytes using holotomography and machine learning

This study uses holotomography and machine learning to classify functional immune states of human monocytes, achieving high accuracy in identifying hyper-inflammatory and immune-suppressed states.

Enhanced functionalities of immune cells separated by microfludic lattice: assessment based on holotomography

This study compares microfluidic and centrifugation methods for isolating white blood cells, finding microfluidic separation better preserves cell functionality.

Hybrid machine-learning framework for volumetric segmentation and quantification of vacuoles in individual unlabeled yeast cells using holotomography

This paper develops a hybrid machine-learning framework to segment and quantify vacuoles in unlabeled yeast cells using holotomography data.

Modulation of neuronal activity in cortical organoids with bioelectronic delivery of ions and neurotransmitters

This study introduces a bioelectronic method to modulate neuronal activity in cortical organoids using ion and neurotransmitter delivery, demonstrating precise control over network activity.

Sequencing, fast and slow: profiling microbiomes in human samples with nanopore sequencing

This study uses nanopore sequencing to rapidly and accurately profile human microbiomes in saliva and stool samples, revealing insights into microbiome composition and host-microbe interactions.

Epistasis facilitates functional evolution in an ancient transcription factor

This study uses combinatorial DMS to analyze the genetic architecture of DNA recognition by an ancient transcription factor, showing that pairwise epistasis enables functional evolution by expanding sequence space for new specificity.

Engrailed-1 Promotes Pancreatic Cancer Metastasis

This study shows EN1 promotes pancreatic cancer metastasis by repressing target genes and enhancing mesenchymal properties.

Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

This study shows that inducing an oxidized redox balance in CD8+ T cells enhances their anti-tumor function in vivo through increased mitochondrial ROS.

DNA nanopores as artificial membrane channels for origami based bioelectronics

The paper develops DNA nanopores integrated with bioprotonic contacts to create efficient artificial ion-channel interfaces for bioelectronic signal readout.

Label-free histological analysis of retrieved thrombi in acute ischemic stroke using optical diffraction tomography and deep learning

This study uses optical diffraction tomography and deep learning to automate thrombus composition analysis in acute ischemic stroke, achieving high accuracy and reducing labor.

High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy

This paper introduces RI-TFM, a high-speed label-free technique for 3D cellular mechanics, and demonstrates its ability to measure traction forces and morphology in cells.

Verification of nucleotide sequence reagent identities in original publications in high impact factor cancer research journals

This study verifies nucleotide sequence reagents in high-impact cancer journals and finds 3.8% and 4.3% of sequences are wrongly identified in Molecular Cancer and Oncogene papers, respectively.

Volumetric refractive index measurement and quantitative density analysis of mouse brain tissue with sub-micrometer spatial resolution

This paper presents a label-free method for high-resolution volumetric imaging and analysis of mouse brain tissue with sub-micrometer spatial resolution.

An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

This study identifies a primate-specific PRDM1 isoform and its interaction with SGK1 as drivers of Treg dysfunction in autoimmune diseases.

CD244 regulates both innate and adaptive immune axes in melanoma by inhibiting autophagy-mediated M1 macrophage maturation

This study shows CD244 inhibits macrophage maturation in melanoma, enhancing T cell responses and improving tumor rejection when combined with PD-L1 blockade.

KDM5A/B promotes HIV-1 latency and KDM5 inhibitors promote HIV-1 lytic reactivation

This study shows that KDM5A/B promote HIV-1 latency and their inhibition with JQKD82, combined with AZD5582, reactivates HIV-1 and induces cell death.

Rapid assessment of susceptibility of bacteria and erythrocytes to antimicrobial peptides by single-cell impedance cytometry

This paper introduces a rapid single-cell method using impedance cytometry to assess antimicrobial peptides' effects on bacteria and erythrocytes, showing high-frequency impedance phase as a reliable metric for activity and toxicity.

Development of Scaffold-free 3D Cholangiocyte Organoids to Study the Progression of Primary Sclerosing Cholangitis

The paper develops scaffold-free 3D cholangiocyte organoids to study primary sclerosing cholangitis progression and confirms PSC-specific phenotypes.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

Long-term label-free assessments of individual bacteria using three-dimensional quantitative phase imaging and hydrogel-based immobilization

This paper introduces a hydrogel-based method for long-term label-free 3D imaging of live bacteria, enabling precise analysis of biophysical parameters and antibiotic responses.

High-fidelity optical diffraction tomography of live organisms using non-toxic tunable refractive index media

This paper introduces a method for high-fidelity optical diffraction tomography using non-toxic RI matching media to improve 3D refractive index reconstruction of live organisms.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.