Author

M. Ota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 5 Organism:human· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2

Frequent Co-Authors

K. Fujio· 4 shared K. Yamamoto· 3 shared A. Suzuki· 2 shared K. Ishigaki· 2 shared M. Nakano· 2 shared S. Sumitomo· 2 shared T. Okamura· 2 shared Y. Kochi· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersImmunology

K. Fujio

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The memory of pathogenic IgE is contained within CD23+IgG1+ memory B cells poised to switch to IgE in food allergy

M. Ota, K. Hoehn, T. Ota, C. Aranda, S. Friedman, W. Braga, A. Malbari, S. Kleinstein, S. Sicherer, M. Curotto de Lafaille

The paper identifies CD23+IgG1+ memory B cells in peanut allergy that can switch to IgE and contain high affinity allergen-specific clones.

bioRxiv · Jan 25, 2023 · PreprintImmunology

An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

T. S. Sumida, M. R. Lincoln, L. He, Y. Park, M. Ota, H. A. Stillwell, G. A. Leissa, K. Fujio, A. Kulminski, C. B. Epstein, B. E. Bernstein, M. Kellis, D. A. Hafler

This study identifies a primate-specific PRDM1 isoform and its interaction with SGK1 as drivers of Treg dysfunction in autoimmune diseases.

bioRxiv · Dec 2, 2022 · PreprintImmunology

Autotaxin is a Potential Link between Genetic Risk Factors and Pathogenesis of Systematic Lupus Erythematosus in Plasmacytoid Dendritic Cells

Y. Tsuchida, H. Shoda, M. Nakano, M. Ota, T. Okamura, K. Yamamoto, M. Kurano, Y. Yatomi, K. Fujio, T. Sawada

The paper investigates autotaxin's role in SLE by analyzing transcriptome and eQTL data, finding elevated autotaxin levels and its association with interferon-related genes in pDCs.

bioRxiv · Oct 25, 2021 · PreprintImmunology

Immune cell multi-omics analysis reveals contribution of oxidative phosphorylation to B cell functions and organ damage of lupus

Y. Takeshima, Y. Iwasaki, M. Nakano, Y. Narushima, M. Ota, Y. Nagafuchi, S. Sumitomo, T. Okamura, K. B. Elkon, K. Ishigaki, A. Suzuki, Y. Kochi, K. Yamamoto, K. Fujio

The paper identifies oxidative phosphorylation (OXPHOS) as a key driver in SLE B cells, linking mitochondrial dysfunction to immune signaling and organ damage.

bioRxiv · Oct 8, 2021 · PreprintImmunology

Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis

H. Tsuchiya, M. Ota, S. Sumitomo, K. Ishigaki, A. Suzuki, T. Sakata, Y. Tsuchida, H. Inui, J. Hirose, Y. Kochi, Y. Kadono, K. Shirahige, S. Tanaka, K. Yamamoto, K. Fujio

This study analyzes multi-omics data from activated synovial fibroblasts to identify genetic risk factors and potential drug targets for rheumatoid arthritis.

bioRxiv · Jun 3, 2020Immunology

Within-Host Diversity and Vertical Transmission of Group B Streptococcus Among Mother-infant Dyads in The Gambia

E. Foster-Nyarko, M. Senghore, B. A. Kwambana-Adams, N.-F. Alikhan, A. Ravi, K. Jawneh, A. Jah, M. Jarju, F. Ceesay, S. Bojang, J. Jafali, A. Worwui, A. Odutola, E. Ogundare, M. J. Pallen, , M. Antonio

The paper investigates GBS transmission from mothers to infants, finding vertical transmission and within-host diversity in one dyad.

bioRxiv · Sep 6, 2019 · PreprintMicrobiology