Oncogenic RAS signaling is a tumor cell-intrinsic determinant of ferroptosis suppression via induction of the GCH1/BH4 axis
J. K. Lim, F. Stoelting, D. Roth, C. Ballmeyer, S. Tishina, L. Thewes, S. Kalis, S. Boussettaoui, D. Picard, H.-F. Zhang, O. Lewandowska, T. Reiff, T. Levy, B. Rotblat, M. Remke, , G. Leprivier
This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.
bioRxiv · Jan 27, 2024 · PreprintCancer Biology