D. Roth

Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice

This study identifies a compound that enhances adult hippocampal neurogenesis and improves behavioral pattern separation in both young and aged mice.

Oncogenic RAS signaling is a tumor cell-intrinsic determinant of ferroptosis suppression via induction of the GCH1/BH4 axis

This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.

Structure-function relationships of mucociliary clearance in human and rat airways

The paper compares mucociliary clearance in human and rat airways, finding species-specific structural differences that affect clearance effectiveness and identifying limitations of lab-grown cultures.

Harnessing Bilayer Biomaterial Delivery of FTY720 as an Immunotherapy to Accelerate Oral Wound Healing

Bilayer FTY720-nanofiber scaffolds promote complete oral wound closure in a mouse model by modulating pro-regenerative immune and stromal cells.

S100A8/A9 predicts triple-negative breast cancer response to PIM kinase and PD-1/PD-L1 inhibition

Primary Ciliary Dyskinesia patient specific hiPSC-derived airway epithelium in Air Liquid Interface culture recapitulates disease specific phenotypes in vitro

The paper develops an in vitro model of PCD using hiPSC-derived airway epithelium that recapitulates disease-specific phenotypes.

Force generation of KIF1C is impaired by pathogenic mutations

This study investigates the force generation of KIF1C and shows that pathogenic mutations impair its ability to generate force, leading to neuronal dysfunction.

Breathing on Chip: Dynamic flow and stretch tune cellular composition and accelerate mucociliary maturation of airway epithelium in vitro

This study shows that applying airflow and stretch to airway epithelial cultures on a chip accelerates mucociliary maturation and alters cellular composition to better mimic airway biology.

Environment-driven reprogramming of gamete DNA methylation occurs during maturation and is transmitted intergenerationally in salmon

This study shows that environmental changes during maturation alter sperm DNA methylation in Atlantic Salmon, which is passed to offspring and linked to fitness differences.

Activation of intracellular transport by relieving KIF1C autoinhibition

This study identifies how PTPN21 relieves KIF1C autoinhibition, enabling cargo-specific transport and bidirectional movement.

Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

This study elucidates the allosteric mechanism of HtrA1 activation through inter-monomer communication, showing its role in proteolytic activity and disease-related pathologies.