D. Picard

The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma

This study shows that EIF4EBP1 is upregulated by MYC in medulloblastoma and linked to poorer patient survival.

Oncogenic RAS signaling is a tumor cell-intrinsic determinant of ferroptosis suppression via induction of the GCH1/BH4 axis

This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.

Hsf1 and the molecular chaperone Hsp90 support a "rewiring stress response" leading to an adaptive cell size increase in chronic stress

The paper shows that chronic mild stress leads to adaptive cell size increase through Hsf1 and Hsp90, enhancing resilience to persistent stress.

UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease

This study identifies UBE2C as a driver of leptomeningeal dissemination in brain metastases and shows that PI3K/mTOR inhibition can prevent its metastatic effects.

4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis

This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.

Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer

The paper identifies effective low-dose multidrug combinations for ER+/HER2-/PI3Kα-mutant breast cancer using network analysis and experimental validation.

CRISPR/Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells

The paper identifies PAICS as a driver of tamoxifen resistance in ER+ breast cancer by promoting estrogen-independent ER activity through cAMP-PKA and mTOR pathways, suggesting combined targeting of PAICS and ER as a therapeutic strategy.

Persister state-directed transitioning and vulnerability in melanoma

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.

EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma

This study shows EIF4EBP1 is upregulated by MYCN and linked to poor prognosis in neuroblastoma, with high expression associated with reduced survival and unfavorable histology.

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis

This study shows TRAP1 forms an OXPHOS-regulated tetramer and is essential for maintaining mitochondrial metabolic homeostasis by modulating OXPHOS and interacting with mitochondrial chaperones.

The Hsp70/Hsp90 Co-Chaperone Hop/Stip1 Shifts the Proteostatic Balance from Folding Towards Degradation

This study shows that Hop/Stip1 regulates proteostasis by shifting the balance between protein folding and degradation in eukaryotes.

The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity

This study shows that cancer cells are hypersensitive to Hsp90 inhibitors due to a shift in cellular quiescence and activity balance, which can be modulated by growth factors and proteostasis challenges.