UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease
E. Paisana, R. Cascao, C. Custodia, N. Qin, D. Picard, D. Pauck, T. Carvalho, P. Ruivo, C. Barreto, D. Doutel, J. Cabecadas, R. Roque, J. Pimentel, J. Miguens, J. T. Barata, C. C. Faria
This study identifies UBE2C as a driver of leptomeningeal dissemination in brain metastases and shows that PI3K/mTOR inhibition can prevent its metastatic effects.
bioRxiv · Oct 4, 2022 · PreprintCancer Biology