Differential effects of PD-1 and CTLA-4 blockade on the melanoma-reactive CD8 T cell response
A. Gangaev, E. A. Rozeman, M. W. Rohaan, D. Philips, S. Patiwael, J. H. van den Berg, A. Ribas, D. Schadendorf, B. Schilling, T. Shumacher, C. Blank, J. B. A. G. Haanen, P. Kvistborg
The paper shows PD-1 blockade in melanoma patients does not increase the breadth or magnitude of melanoma-reactive CD8 T cells in peripheral blood, suggesting PD-1 acts mainly at the tumor site.
bioRxiv · Dec 15, 2020Immunology