ImmunologybioRxiv
Differential effects of PD-1 and CTLA-4 blockade on the melanoma-reactive CD8 T cell response
A. Gangaev, E. A. Rozeman, M. W. Rohaan…·P. Kvistborg
The paper shows PD-1 blockade in melanoma patients does not increase the breadth or magnitude of melanoma-reactive CD8 T cells in peripheral blood, suggesting PD-1 acts mainly at the tumor site.
DOI 10.1073/pnas.2102849118