Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria
P. Labana, M. H. Dornan, M. Lafreniere, T. L. Czarny, E. D. Brown, J. P. Pezacki, C. Boddy
This study identifies armeniaspirol as an antibiotic that inhibits ClpXP and ClpYQ proteases in Gram-positive bacteria, disrupting cell division and showing potential as a new antibiotic class.
bioRxiv · Sep 4, 2020Microbiology