MicrobiologybioRxiv
Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria
P. Labana, M. H. Dornan, M. Lafreniere…·C. Boddy
This study identifies armeniaspirol as an antibiotic that inhibits ClpXP and ClpYQ proteases in Gram-positive bacteria, disrupting cell division and showing potential as a new antibiotic class.
DOI 10.1016/j.chembiol.2021.07.001