E. D. Brown

Micro-plaque assays: A high-throughput method to detect, isolate, and characterize bacteriophages

This paper introduces micro-plaque assays to improve phage isolation and characterization, showing they can isolate 21 unique phages from one sample and identify phage susceptibility in clinical strains.

Screening under infection-relevant conditions reveals chemical sensitivity in multidrug-resistant invasive non-typhoidal Salmonella (iNTS)

This study identifies chemical sensitivities in multidrug-resistant iNTS Salmonella under infection-relevant conditions, revealing potential drug targets.

Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics

This study identifies central metabolism and respiration as key drivers of E. coli biofilm formation in response to sub-MIC antibiotics.

Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa

This study identifies ruthenium complexes as effective antibiotics against Pseudomonas aeruginosa, showing in vivo efficacy and synergy with rifampicin.

Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria

This study identifies armeniaspirol as an antibiotic that inhibits ClpXP and ClpYQ proteases in Gram-positive bacteria, disrupting cell division and showing potential as a new antibiotic class.

Uncovering the hidden antibiotic potential of Cannabis

This study investigates the antibacterial properties of cannabinoids, showing efficacy against MRSA and Gram-negative bacteria, and their potential as therapeutic agents.

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

The paper identifies antibacterial compounds effective against intracellular Salmonella Typhimurium through macrophage-based screens and shows metergoline enhances activity by perturbing the bacterial outer membrane.