TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling
J. Engelmann, J. Zarrer, M. J. Schmerder, C. Mess, D. Ragipoglu, K. Riecken, T. Burstyn-Cohen, E. Alberto, S. Ghosh, C. V. Rothlin, K. Pantel, C. Bokemeyer, E. Hesse, H. Taipaleenmaeki, S. Loges, I. Ben-Batalla
This paper identifies TAM receptors MERTK and TYRO3 in osteoclasts regulating bone homeostasis through RHOA-COFILIN-MYOSIN II signaling, with MERTK promoting osteoclast formation and TYRO3 inhibiting it.
bioRxiv · Apr 12, 2024 · PreprintCell Biology