S. Ghosh

Mechanism of host cell invasion by Leishmania through KMP-11 mediated cholesterol-transport and membrane phase transition

This paper identifies KMP-11 as a key Leishmania protein that mediates host cell invasion via cholesterol transport and membrane phase transition.

Proteome-Wide Bioinformatic Annotation and Functional Validation of the Monotopic Phosphoglycosyl Transferase Superfamily

The paper identifies and validates substrate specificity of bacterial monotopic phosphoglycosyl transferases using bioinformatics and in vitro assays, supporting inhibitor discovery for antibiotic development.

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

Kingdom-specific lipid unsaturation shapes up sequence evolution in membrane arm subunits of eukaryotic respiratory complexes

The paper investigates how lipid-protein interactions constrain sequence evolution in membrane subunits of eukaryotic respiratory complexes, finding that lipid-exposed surfaces show non-PPI disease mutations and kingdom-specific lipid unsaturation affects stability.

Structure-function relationship of PE11 esterase of Mycobacterium tuberculosis with respect to its role in virulence

This study characterizes the structure and function of PE11 esterase from Mycobacterium tuberculosis, showing its role in virulence and potential as a therapeutic target.

Electroencephalogram (EEG) Classification using a bio-inspired Deep Oscillatory Neural Network

This paper introduces two oscillatory neural networks for EEG classification and prediction tasks, incorporating brain dynamics through nonlinear oscillators.

Mechanical Analysis of Cell Migration Using Hybrid Structural Optimization

This paper develops a biophysical model to predict F-actin stress fiber localization and force during cell migration using cell trajectory data from time lapse microscopy.

Infection of Alfalfa Cotyledons by an Incompatible but Not a Compatible Species of Colletotrichum Induces Formation of Paramural Bodies and Secretion of EVs

This study compares subcellular changes in alfalfa cotyledons infected by compatible and incompatible Colletotrichum species, finding that incompatible infection leads to paramural body formation and increased extracellular vesicle secretion.

Multi-omic Analysis Identifies Glioblastoma Dependency on H3K9me3 Methyltransferase Activity

This study identifies H3K9me3 methyltransferases as key drivers in glioblastoma, showing their association with prognosis, immune response, and drug response through multi-omics analysis.

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

This paper identifies TAM receptors MERTK and TYRO3 in osteoclasts regulating bone homeostasis through RHOA-COFILIN-MYOSIN II signaling, with MERTK promoting osteoclast formation and TYRO3 inhibiting it.

Plant Development Drives Dynamic Shifts in the Root Compartment Microbiomes of Wild and Domesticated Finger Millet Cultivars

This study examines how plant developmental stage and domestication influence microbial communities in root compartments of finger millet, showing significant shifts in bacterial and fungal phyla.

Crude extract of Ruellia tuberosa L. flower induces intracellular ROS, promotes DNA damage and apoptosis in Triple Negative Breast Cancer Cells

This study shows that the methanolic extract of Ruellia tuberosa L. flower induces ROS, causes G0/G1 cell cycle arrest, and promotes apoptosis in TNBC cells without toxicity in mice.

Enhanced extracellular matrix remodeling due to embedded spheroid fluidization

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

Assessment of Antibiotic Resistance Profiles in Cultivable Coliform Organisms Isolated from Ganga River Waters Across the Upper, Middle, and Lower Ganga Stretch

The paper assesses antibiotic resistance in coliforms from Ganga River waters, finding varying resistance levels across different river stretches.

Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

Addressing anemia severity in antimony-resistant Leishmania donovani infection at the nexus of oxidative outburst and iron transit

This study investigates how antimony-resistant Leishmania donovani strains manage iron and oxidative stress, leading to anemia, and identifies potential therapeutic targets.

The adoption of a westernized gut microbiome in Indian Immigrants and Indo-Canadians is associated with dietary acculturation

The study compares gut microbiomes of Indians, Indo-Immigrants, Indo-Canadians, and Euro-Canadian controls to assess the impact of dietary acculturation on microbiome composition and IBD risk.

Evaluation Of Suitability Analysis of Gangetic Water from Upper, Middle, And Lower Ganga Rivers

This study evaluates water quality across the Ganga River's upper, middle, and lower stretches to determine suitability for drinking, irrigation, and industrial use, highlighting variations in parameters like E. coli, sodium levels, and heavy metals.

Unraveling the Interplay between Phytochemicals and Rhizosphere Bacteria in Ficus racemosa

This study examines how phytochemicals in Ficus racemosa influence rhizosphere bacterial communities through microbiology and phytochemistry integration.

A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs

This paper introduces a platform for high-throughput extraction of membrane proteins into native nanodiscs while preserving their local membrane context and provides a database for optimized extraction conditions.

Chromosome-scale genome assembly of bread wheat's wild relative Triticum timopheevii

This study presents a chromosome-scale genome assembly of Triticum timopheevii using PacBio HiFi and Hi-C data, revealing genomic features and relationships between wheat genomes.

Northeast India: Genetic Inconsistency across Ethnicity and Geography

The paper analyzes the genetic structure of Northeast India, finding a complex interplay between language, ethnicity, and geography, with a novel Trans-Himalayan ancestry uniting the region.

Hyperoxia Induced Alteration of Chromatin Structure in Bone Marrow Derived Primary Mesenchymal Stromal Cells

This study investigates how hyperoxia alters chromatin structure in mesenchymal stromal cells using imaging techniques and finds spatiotemporal variability in chromatin remodeling and its inhibition by GSK126.

Chromatin Remodeling and Epigenetic Modifications in Planar Cell Migration

This study shows that chromatin remodeling and epigenetic modifications influence cell migration speed and wound closure efficiency on planar substrates.

Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.

This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.

Gestures Of Hunger: Uncovering Intentional Gestural Communication In Free-Ranging Hanuman Langurs

This study identifies intentional gestural communication in Hanuman langurs, showing they use learned gestures to request food from humans and adapt this behavior as a foraging strategy.

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

The microbial metabolite Urolithin A reduces C. difficile toxin expression and repairs toxin-induced epithelial damage.

This study shows that urolithin A reduces C. difficile toxin production and repairs epithelial damage in a preclinical colitis model.

A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.