Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases
M. W. Pesesky, R. Bharanikumar, L. W. Le Bourhis, H. ElAbd, E. Rosati, C. Carty, N. Singh, B. Bokemeyer, S. Schreiber, S. Goerg, M. G. Noceda, P. Chapfuwa, R. M. Gittelman, D. H. May, J. N. Dines, , M. Allez
The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.
bioRxiv · May 15, 2024Immunology