N. Singh

MYB transcription factor, NtMYB308, regulates anthocyanin and lignin content, and fungal tolerance in tobacco

This study identifies NtMYB308 as a negative regulator of anthocyanin and lignin biosynthesis in tobacco, which influences fungal tolerance.

The contribution of small protected areas to the big picture of forest conservation and restoration in Sweden

The paper assesses the contribution of small protected areas in Sweden to forest conservation and restoration over 30 years, finding they are critical but underrepresented and in decline.

Programmable soft DNA hydrogels stimulate cellular endocytic pathways and proliferation

This paper develops DNA-based hydrogels that stimulate cellular endocytic pathways and proliferation by mimicking in vivo environments through programmable supramolecular structures.

Self-assembled DNA-collagen bioactive scaffolds promote cellular uptake and neuronal differentiation

This study develops self-assembled DNA-collagen scaffolds that enhance cellular uptake and promote neuronal differentiation of precursor cells.

Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases

The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.

Unraveling Systemic Responses to NQO1-Activated IB-DNQand Rucaparib Single and Dual Agent Therapy in Triple-Negative Breast Cancers

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

T2R14 mediated antimicrobial responses through interactions with CFTR

The paper investigates the interaction between T2R14 and CFTR, showing agonist-dependent physical coupling and Gq signaling in response to microbial signals.

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

HY5 and COP1 function antagonistically in the light-dependent regulation of nicotine biosynthesis in tobacco

This study shows that HY5 and COP1 antagonistically regulate light-dependent nicotine biosynthesis in tobacco by modulating shoot-to-root transport of HY5.

Rational protein engineering to enhance MHC-independent T cell receptors

The paper designs MHC-independent T cell receptors (miTCRs) to enhance cancer immunotherapy by improving receptor stability and function through structural modeling and iterative sequence modifications.

Characterization Of Bitter Taste Receptor Dependent Autophagy in Oral Epithelial Cells

The paper characterizes T2R14-dependent autophagy in gingival epithelial cells using western blot and flow cytometry to assess autophagy flux.

Bitter taste receptor T2R14 and autophagy flux in gingival epithelial cells

This study shows that T2R14 downregulates autophagy flux in gingival epithelial cells and that S. mutans CSP-1 induces calcium release dependent on T2R14 and autophagy protein 7.

3-epicaryoptin induces G2/M phase cell cycle arrest and apoptosis in human breast cancer cells by disrupting the microtubule network, an in vitro and in silico investigation

This study investigates 3-epicaryoptin's anti-cancer effects on MCF-7 cells, showing it induces G2/M arrest and apoptosis by disrupting microtubules.

Intronic miR-6741-3p is involved in oral squamous cell carcinoma pathogenesis by targeting the oncogene SRSF3

This study identifies miR-6741-3p as a tumor suppressor in oral squamous cell carcinoma by targeting SRSF3, showing its potential as a therapeutic target.

Genomic location dictates lytic promoter activity during herpes simplex virus latency

The paper shows that lytic gene promoters in HSV-1 are active during latency only when located near the LAT locus.

The effect of clinically relevant beta-lactam, aminoglycoside, and quinolone antibiotics on bacterial extracellular vesicle release from E. coli

This study examines how clinically relevant antibiotics affect extracellular vesicle release from E. coli, finding that beta-lactams increase release while quinolones and aminoglycosides decrease it.

Tick extracellular vesicles alter keratinocyte function in the skin epidermis

This study shows that tick extracellular vesicles alter keratinocyte function in the epidermis by inhibiting proliferation and wound closure, linked to phosphoinositide 3-kinase, KGF-1, and TGF-β.

Rab27 in tick extracellular vesicle biogenesis and infection

This study identifies Rab27 as essential for tick extracellular vesicle biogenesis and its role in bacterial acquisition during feeding.

MtbEis protein: A new player in stringent response of Mycobacterium tuberculosis

This study identifies MtbEis as an acetyltransferase that enhances RelMtb's pppGpp synthesis, improving M. tuberculosis survival under starvation conditions.

Angiopoietin-like protein 2 mediates vasculopathy driven fibrogenesis in a mouse model of systemic sclerosis

This study identifies Angptl2 as a driver of fibrotic vasculopathy in a mouse model of SSc and shows that inhibiting its effects can reduce fibrogenesis.

Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis

The paper identifies two non-canonical L-cysteine synthases in Mtb, CysM and CysK2, which support divergent biosynthetic pathways critical for redox stress response and survival during infection.

Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

This study identifies cardiac glycosides that restore autophagy and gene expression in an iPSC model of WDR45 deficiency, suggesting potential therapeutic applications for BPAN.

Tick hemocytes have pleiotropic roles in microbial infection and arthropod fitness

This study identifies hemocyte heterogeneity and pleiotropic roles in ticks using multi-omics approaches, revealing their impact on immunity, metabolism, and arthropod fitness.

p53 amyloid pathology with cancer grades and p53 mutations

The paper shows p53 amyloid load correlates with cancer grades and shows both mutant and wild-type p53 form amyloids in cancer tissues.

Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity

This study investigates the role of EpOMEs and DiHOMEs in insect immune resolution, showing EpOMEs suppress immune responses while DiHOMEs enhance antimicrobial peptide expression, and their dysregulation increases susceptibility to pathogens.

Metabolic disruption impacts tick fitness and microbial relationships

This study shows that metabolic changes in ticks affect their fitness and interactions with microbes, highlighting the role of BAIBA in these relationships.

PROTEOMICS OF HYPOTHERMIC ADAPTATION REVEALS THAT RBM3 ENHANCES MITOCHONDRIAL METABOLISM AND MUSCLE STEM-CELL DIFFERENTIATION

This study identifies RBM3 as a key mediator of hypothermic adaptation in skeletal muscle myoblasts, showing it enhances mitochondrial metabolism and muscle stem-cell differentiation.

Identification of merozoite secreted repertoire and immuno-pharmacological inhibition of a novel host-parasite interaction to block malarial infection

This study identifies the secretory repertoire of Plasmodium merozoites and discovers a peptide that disrupts a key host-parasite interaction, blocking malarial infection.

Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity and neutralization sensitivity

This study investigates how mutations in the S2 subunit of SARS-CoV-2 Omicron spike affect its structure, fusogenicity, and neutralization sensitivity.

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.