Author

C. Chaguza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. D. Bentley· 2 shared A. Alisoltani· 1 shared A. E. Green· 1 shared A. Iranzadeh· 1 shared A. K. Pöntinen· 1 shared A. Kiran· 1 shared A. R. Freitas· 1 shared C. Munro· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

S. D. Bentley

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3 papers

Recent·Most cited

Pan-genome study underlining the extent of genomic variation of invasive Streptococcus pneumoniae in Malawi

A. Iranzadeh, A. Alisoltani, A. Kiran, R. Breiman, C. Chaguza, C. Peno, J. E. Cornick, D. B. Everett, N. Mulder

This study identifies serotypes 1 and 5 of Streptococcus pneumoniae as highly invasive in Malawi, showing genetic differences linked to shorter colonization and potential invasiveness.

bioRxiv · Jan 2, 2023 · PreprintMicrobiology

The population-level impact of Enterococcus faecalis genetics on intestinal colonisation and extraintestinal infection

C. Chaguza, A. K. Pöntinen, J. Top, S. Arredondo-Alonso, A. R. Freitas, C. Novais, C. Torres, S. D. Bentley, L. Peixe, T. M. Coque, R. J. L. Willems, J. Corander

This study investigates the genetic factors influencing E. faecalis intestinal colonization and extraintestinal infection using GWAS and heritability analysis across 750 isolates.

bioRxiv · Sep 26, 2022 · PreprintMicrobiology

Identification of colonisation and virulence determinants of Streptococcus pneumoniae via experimental evolution in mouse infection models

A. E. Green, D. Howarth, C. Chaguza, H. Echlin, R. F. Langendonk, C. Munro, T. E. Barton, J. C. Hinton, S. D. Bentley, J. Rosch, D. R. Neill

This study uses experimental evolution in mouse models to identify genetic factors affecting Streptococcus pneumoniae colonization and virulence.

bioRxiv · Sep 8, 2020 · PreprintMicrobiology