Deep mutational scanning of essential bacterial proteins can guide antibiotic development
L. Dewachter, A. N. Brooks, K. Noon, C. Cialek, A. Clark-ElSayed, T. Schalck, N. Krishnamurthy, W. Versees, W. Vranken, J. Michiels
This study uses deep mutational scanning on E. coli proteins to identify antimicrobial targets and guide drug development by analyzing mutation effects and resistance potential.
Nature Communications · Jan 16, 2023Peer-reviewedMicrobiology