Author

J. Michiels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:E. coli· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Wilmaerts· 3 shared B. Van den Bergh· 2 shared L. Dewachter· 2 shared P. Matthay· 2 shared A. Clark-ElSayed· 1 shared A. N. Brooks· 1 shared C. Bollen· 1 shared C. Cialek· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

D. Wilmaerts

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

In vitro persistence level reflects in vivo antibiotic survival of natural Pseudomonas aeruginosa isolates in a murine lung infection model

L. Verstraete, J. Aizawa, M. Govaerts, L. De Vooght, J. Michiels, B. Van den Bergh, P. Cos

The paper shows that in vitro persistence levels of Pseudomonas aeruginosa correlate with in vivo survival in a mouse lung infection model, validating classical persistence assays for clinical relevance.

bioRxiv · Oct 21, 2022Microbiology

Deep mutational scanning of essential bacterial proteins can guide antibiotic development

L. Dewachter, A. N. Brooks, K. Noon, C. Cialek, A. Clark-ElSayed, T. Schalck, N. Krishnamurthy, W. Versees, W. Vranken, J. Michiels

This study uses deep mutational scanning on E. coli proteins to identify antimicrobial targets and guide drug development by analyzing mutation effects and resistance potential.

bioRxiv · May 23, 2022Microbiology

Transcription-coupled DNA repair underlies variation in persister awakening and the emergence of resistance

D. Wilmaerts, C. Focant, P. Matthay, J. Michiels

This study shows that transcription-coupled DNA repair mechanisms influence persister awakening and resistance development in bacteria.

bioRxiv · Jul 29, 2021 · PreprintMicrobiology

Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA

G. Garcia-Rodriguez, D. Charlier, D. Wilmaerts, J. Michiels, R. Loris

This study identifies the structural basis of RnlA activity and inhibition through dimerization and residue-specific interactions.

bioRxiv · Mar 22, 2021Biophysics

The dynamic transition of persistence towards the VBNC state during stationary phase is driven by protein aggregation

L. Dewachter, C. Bollen, D. Wilmaerts, E. Louwagie, P. Herpels, P. Matthay, L. Khodaparast, L. Khodaparast, F. Rousseau, J. Schymkowitz, J. Michiels

This study shows that bacterial persistence during stationary phase is linked to protein aggregation and ATP depletion, with ObgE playing a role in triggering this process.

bioRxiv · Feb 15, 2021Microbiology

Isolation of persisters enabled by ss-lactam-induced filamentation reveals their single-cell awakening characteristics

E. M. Windels, Z. Ben Meriem, T. Zahir, K. J. Verstrepen, P. Hersen, B. Van den Bergh, J. Michiels

This study isolates persisters using cephalexin-induced filamentation and shows that persister awakening is stochastic at the single-cell level.

bioRxiv · Apr 6, 2019 · PreprintMicrobiology