Author

L. Dewachter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. Michiels· 2 shared A. Clark-ElSayed· 1 shared A. N. Brooks· 1 shared C. Bollen· 1 shared C. Cialek· 1 shared C. Costa· 1 shared D. Wilmaerts· 1 shared E. Louwagie· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

J. Michiels

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Deep mutational scanning of essential bacterial proteins can guide antibiotic development

L. Dewachter, A. N. Brooks, K. Noon, C. Cialek, A. Clark-ElSayed, T. Schalck, N. Krishnamurthy, W. Versees, W. Vranken, J. Michiels

This study uses deep mutational scanning on E. coli proteins to identify antimicrobial targets and guide drug development by analyzing mutation effects and resistance potential.

bioRxiv · May 23, 2022Microbiology

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

L. Dewachter, X. Liu, J. Denereaz, V. de Bakker, C. Costa, M. Baldry, J.-C. Sirard, J.-W. Veening

This paper identifies the mevalonate pathway as a target to resensitize amoxicillin-resistant Streptococcus pneumoniae using sCRilecs-seq.

bioRxiv · Sep 13, 2021Microbiology

The dynamic transition of persistence towards the VBNC state during stationary phase is driven by protein aggregation

L. Dewachter, C. Bollen, D. Wilmaerts, E. Louwagie, P. Herpels, P. Matthay, L. Khodaparast, L. Khodaparast, F. Rousseau, J. Schymkowitz, J. Michiels

This study shows that bacterial persistence during stationary phase is linked to protein aggregation and ATP depletion, with ObgE playing a role in triggering this process.

bioRxiv · Feb 15, 2021Microbiology