Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity
J. Ordovas-Montanes, D. F. Dwyer, S. K. Nyquist, K. M. Buchheit, C. Deb, M. H. Wadsworth, T. K. Hughes, S. W. Kazer, E. Yoshimoto, N. Bhattacharyya, H. R. Katz, T. M. Laidlaw, J. A. Boyce, N. A. Barrett, A. K. Shalek
This study profiles single-cell RNA-seq data from human respiratory tissues to show reduced epithelial diversity and altered basal progenitor states in type 2 immunity-driven diseases.
bioRxiv · Nov 14, 2017Immunology