M. H. Wadsworth

This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.

Tobacco smoke exposure recruits inflammatory monocytes to the lungs, which support faster Mycobacterium tuberculosis growth.

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

This study uses single-cell profiling to analyze P. vivax liver infection, identifying host and parasite transcriptional signatures and revealing new insights into parasite dormancy and host responses.

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

This study uses single-cell RNA-sequencing to analyze prostate cancer tumor microenvironment, identifying heterogeneous epithelial cell states and tumor-associated club cells.

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

This study shows that GM-CSF differentiation of human monocytes reduces IL-10 production through oxidative signaling, highlighting its role in macrophage function and plasticity.

This study uses single-cell transcriptomics and protein profiling to analyze EBOV infection in rhesus monkeys, revealing changes in immune cell dynamics and viral/host gene expression.

This study identifies BFD1 as a master regulator of differentiation in Toxoplasma gondii through genetic screening and single-cell profiling, showing its necessity and sufficiency for the transition from tachyzoites to bradyzoites.

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.

This study profiles single-cell RNA-seq data from human respiratory tissues to show reduced epithelial diversity and altered basal progenitor states in type 2 immunity-driven diseases.