The ability of the LIMD1 and TRIP6 LIM domains to bind to f-actin under strain is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1.
S. Ray, C. DeSilva, I. Dasgupta, S. Mana-Capelli, N. Cruz-Calderon, D. McCollum
This study shows that TRIP6 and LIMD1 bind to strained actin, enabling their localization to adherens junctions and interaction with LATS1, a key Hippo pathway kinase.
bioRxiv · Oct 12, 2023 · PreprintCell Biology