S. Ray

The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

This study analyzes the antigenic diversity of N2 neuraminidases from 2009-2017 H3N2 influenza viruses and develops a machine learning method to predict the impact of mutations on NA inhibition.

Comparing physiological impacts of positive pressure ventilation versus self-breathing via a versatile cardiopulmonary model incorporating a novel alveoli opening mechanism

3-epicaryoptin induces G2/M phase cell cycle arrest and apoptosis in human breast cancer cells by disrupting the microtubule network, an in vitro and in silico investigation

This study investigates 3-epicaryoptin's anti-cancer effects on MCF-7 cells, showing it induces G2/M arrest and apoptosis by disrupting microtubules.

Viral protease NIa-Pro increases MEDIATOR SUBUNIT16 cleavage and plant susceptibility to turnip mosaic virus and its aphid vector Myzus persicae.

This study shows that the viral protease NIa-Pro cleaves MED16, reducing plant defenses against TuMV and its aphid vector, thereby increasing virus and aphid performance.

The ability of the LIMD1 and TRIP6 LIM domains to bind to f-actin under strain is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1.

This study shows that TRIP6 and LIMD1 bind to strained actin, enabling their localization to adherens junctions and interaction with LATS1, a key Hippo pathway kinase.

Innate attraction and aversion to odors in locusts

The paper investigates innate odor preferences in locusts, finding that hatchlings prefer food odor blends but have varying responses to individual components depending on concentration.

High-resolution structures map the metal import pathway in an Nramp transporter

The paper presents high-resolution structures of the Nramp transporter from Deinococcus radiodurans in different conformations, revealing insights into metal coordination and transport mechanisms.

Phenol Sensing in Nature Modulated via a Conformational Switch Governed by Dynamic Allostery

The paper shows that MopR, an NtrC protein, uses dynamic allostery to sense phenol, altering its conformation and ATPase activity, with implications for evolutionary conservation.

Mass photometric detection and quantification of nanoscale α-synuclein phase separation

This study uses mass photometry to detect and quantify nanoscale α-synuclein phase separation, revealing its occurrence under a wider range of conditions than previously thought.

Functional Requirements for a Samd14-Capping Protein Complex in Stress Erythropoiesis

This study identifies a Samd14-CP complex interaction that promotes stress erythropoiesis by enhancing SCF/c-Kit signaling in erythroid precursors.

Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions

The paper demonstrates that proteins and polypeptides can form liquid condensates under high intermolecular interaction conditions, showing that LLPS is a common state across diverse molecular structures.

Spatiotemporal solidification of α-synuclein inside the liquid droplets

This study investigates the spatiotemporal solidification of α-synuclein within liquid droplets, showing how solid-like cores form and propagate during droplet aging and fusion.

Actin capping protein regulates actomyosin contractility to maintain germline architecture in C. elegans

This study shows that CAP-1 regulates actomyosin contractility in C. elegans germline, maintaining structure and fertility by controlling F-actin and myosin II levels.

The potyviral protein 6K1 reduces plant protease activity during Turnip mosaic virus infection

This study shows that the TuMV 6K1 protein reduces protease activity and affects jasmonic acid biosynthesis, enhancing virus accumulation in systemic leaves.

Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids

This study investigates co-aggregation and cross-seeding between prolactin and galanin in rat lactotrophs, revealing a novel mechanism of heterologous amyloid formation with implications for functional and pathological amyloids.

Cytotoxic and micronuclei inducing effects of petroleum ether fraction of leaf aqueous extract of Clerodendrum viscosum Vent. in Allium cepa root tip cells

This study evaluates the cytotoxic and micronuclei-inducing effects of a petroleum ether fraction from Clerodendrum viscosum on Allium cepa root tip cells, showing concentration-dependent toxicity and mitotic abnormalities.

Comparative in vitro antioxidant and antibacterial activities of leaf extract fractions of Crimson bottlebrush, Callistemon citrinus (Curtis.) Skeels

This study compares the antioxidant and antibacterial activities of different extract fractions from Callistemon citrinus leaves, finding the aqueous fraction has highest antioxidant activity while petroleum ether has highest antibacterial activity.

Cytogenotoxic effects of 3-epicaryoptin in Allium cepa L. root apical meristem cells

This study evaluates the cytogenotoxic effects of 3-epicaryoptin on Allium cepa root apical meristem cells, showing concentration-dependent growth inhibition and chromosomal abnormalities.

Leaf Aqueous Extract of Manilkara hexandra influenced Glucose Metabolism in fish: An observation with Labeo rohita Fingerlings as model organism

This study investigates the hypoglycaemic effect of Manilkara hexandra leaf extract on glucose metabolism in Labeo rohita fingerlings by analyzing enzyme activities and serum glucose levels.

Deciphering colchicine like actions of clerodin in terms of microtubule destabilization based mitotic abnormalities, G2/M-phase arrest, and plant polyploidy

This study shows clerodin induces mitotic abnormalities, G2/M arrest, and polyploidy in cells, similar to colchicine, through microtubule destabilization and shared binding site interaction.

Comparative assessment of allelopathic herbicidal actions and total phenolics content of seven Indian medicinal plants

This study compares allelopathic effects and total phenolics content of seven Indian medicinal plants, finding Crinum asiaticum leaf extract shows the strongest inhibitory activity.

Comparative phytotoxicity and chironomid toxicity assessments of leaf successive extract fractions of Asiatic poison bulb, Crinum asiaticum L.

This study compares the phytotoxicity and chironomid toxicity of different extract fractions from Crinum asiaticum, finding the ethyl acetate fraction most toxic and the last aqueous fraction least toxic.

Cell Cycle Delay, Pro-metaphase Arrest and C-metaphase Inducing Effects of Petroleum Ether Fraction of Leaf Aqueous Extract of Clerodendrum viscosum Vent.

This study examines the effects of a petroleum ether fraction from Clerodendrum viscosum on cell cycle delay and metaphase arrest in A. cepa root tip cells.

Channeling macrophage polarization via selective translation inhibition by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

This study shows rocaglates shift macrophage polarization toward M1-like by inhibiting IL-4 response and enhancing resistance to Mycobacterium tuberculosis.

APEX2 proximity proteomics resolves flagellum subdomains and identifies flagellum tip-specific proteins in Trypanosoma brucei

This paper uses APEX2 proximity proteomics to identify flagellum subdomain-specific proteins in Trypanosoma brucei, revealing tip-specific proteins involved in signal transduction.

A bacterial resolvase first exploits, then constrains intrinsic dynamics of the Holliday junction to direct recombination

This study investigates how the bacterial resolvase RuvC uses and limits Holliday junction dynamics to select specific strands for cleavage during recombination.

Arterial carboxyhaemoglobin levels in children admitted to PICU: a retrospective observational study

This study examines COHb levels in critically ill children, finding higher levels in younger patients and associations with longer ventilation and mortality.

Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations

This paper uses alchemical free-energy calculations to predict how Abl mutations affect inhibitor affinity, achieving accurate results for clinical mutations.