Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression
T. N. Cordeiro, N. Sibille, P. Germain, P. Barthe, A. Boulahtouf, F. Allemand, R. Bailly, V. Vivat, C. Ebel, A. Barducci, W. Bourguet, A. le Maire, P. Bernado
This study shows that the structural dynamics of the H12 helix in RXR/RAR heterodimers and the intrinsic disorder of N-CoR regulate gene expression through conformational changes and corepressor complex formation.
bioRxiv · Oct 25, 2018Biophysics