P. Barthe

Understanding the physical determinants of pressure denaturation: Exploring the unfolding pathways of Yfh1 at different temperatures with High-Pressure NMR

The paper investigates the unfolding pathways of the yeast protein Yfh1 under pressure and different temperatures using high-pressure NMR, revealing similarities and differences in the mechanisms of denaturation.

A Mycobacterium tuberculosis effector targets mitochondrion, controls energy metabolism and limits cytochrome c exit.

This study identifies Rv1813c, a Mycobacterium tuberculosis effector that targets mitochondria, enhances ATP production, and delays cytochrome c release, thereby modulating host metabolism and apoptosis.

Structural genomic applied on the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine-knot and nuclear transport factor 2-like protein folds

The paper identifies two effector proteins from the rust fungus Melampsora larici-populina that adopt structural folds similar to knottin and nuclear transport factor 2-like proteins despite lacking sequence similarity.

Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the global transcriptional regulator Lsr2

This study shows that PknB phosphorylates Lsr2, affecting its DNA binding and M. tuberculosis growth under hypoxia.

Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression

This study shows that the structural dynamics of the H12 helix in RXR/RAR heterodimers and the intrinsic disorder of N-CoR regulate gene expression through conformational changes and corepressor complex formation.

Monitoring Unfolding of Titin I27 single- and bi-Domain with High-Pressure NMR Spectroscopy.

This study uses high-pressure NMR to analyze the unfolding of titin I27 domains, confirming the AG β-sheet as a critical structural element and revealing differences from previous MD simulation findings.