ALT Neuroblastoma Chemoresistance due to ATM Activation by Telomere Dysfunction is Reversible with the ATM Inhibitor AZD0156
B. Koneru, A. Farooqi, T. H. Nguyen, W. H. Chen, A. Hindle, C. Eslinger, M. R. Makena, T. A. Burrow, J. Wilson, A. Smith, V. P. Reddy, E. Cadogan, S. T. Durant, C. P. Reynolds
This study shows that ATM activation due to telomere dysfunction causes chemoresistance in ALT neuroblastoma, which can be reversed by the ATM inhibitor AZD0156.
bioRxiv · Apr 6, 2021Cancer Biology