A. Smith

ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

Single-cell imaging of the lytic phage life cycle in bacteria

This study uses time-lapse imaging to analyze phage infection dynamics in bacteria, revealing heterogeneity and its impact on phage fitness.

Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes

The paper investigates the dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes, revealing expanded piwil1 genes and divergent piRNA-producing loci.

NRP1-expressing myeloid cells promote arteriogenesis in the ischemic limb

The paper identifies NRP1-expressing myeloid cells as promoters of arteriogenesis in ischemic limbs and suggests their therapeutic potential.

Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

Zotatifin targets EIF4A to suppress TNBC by inhibiting Sox4, inducing interferon response, and reprogramming the tumor immune microenvironment, synergizing with chemotherapy.

Light management by algal aggregates in living photosynthetic hydrogels.

This study investigates how algal aggregates in hydrogels improve light distribution and biomass growth by reducing photoinhibition and increasing light penetration.

Antimicrobial efficacy of in-situ plasma-generated ozone against Pseudomonas aeruginosa biofilms in drains and water-submerged surfaces

This study demonstrates plasma-generated ozone effectively reduces biofilms in plumbing systems, achieving 5-6 log10 bioburden reduction in drains and sinks.

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer

This study evaluates a DNA vaccine, PlaCCine, showing strong immunogenicity and protection in mice against SARS-CoV-2 variants.

Salmonella Infantis, the emerging human multidrug resistant pathogen - a One Health perspective

The paper analyzes whole genome sequences of Salmonella Infantis strains to identify genetic clusters, AMR determinants, and plasmid presence across different sources and regions.

Phenotypic plasticity shapes biofilm's structure and fluid transport enhancing resilience

The paper investigates how phenotypic plasticity in Bacillus subtilis biofilms enhances resilience through spatial organization and fluid transport properties.

Model-based evaluation of critical nursery habitats for juvenile blue crabs through ontogeny: abundance and survival in seagrass, salt marsh, and unstructured bottom

This study evaluates abundance and survival of juvenile blue crabs across seagrass, salt marsh, and sand habitats, finding seagrass supports small juveniles and salt marsh supports larger ones, with survival linked to habitat structure and size.

Individuals lack the capacity to accurately detect emotional piloerection

The paper shows humans cannot accurately detect their own piloerection events, with self-reports often mismatching observable occurrences.

Ontogenetic Patterns in Juvenile Blue Crab density: Effects of Habitat and Turbidity in a Chesapeake Bay Tributary

This study examines size-specific habitat use and turbidity effects on juvenile blue crab density in different estuarine habitats during recruitment.

Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR

This study develops an efficient ribonucleoprotein-based CRISPR method for editing human intestinal organoids, achieving 98% editing efficiency with no off-target effects and revealing PTEN loss phenotypes.

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

This study identifies monocarboxylate transporters (MCTs) as facilitators of succinate uptake into brown adipocytes, showing their role in metabolic disease protection.

Long-term ecological responses of a Dipterocarp forest to climate changes and nutrient availability

This study examines how Dipterocarp forests in the Philippines responded to past climate changes and nutrient availability over 1,400 years, finding that drier conditions and phosphorus levels influenced tree abundance and productivity.

Toxin-mediated downregulation of absorptive ion transporters NHE3, DRA, and SGLT1 in the colon contributes to diarrhea associated with Clostridioides difficile infection.

This study shows CDI reduces NHE3, DRA, and SGLT1 in the colon, impairing ion transport and causing osmotic diarrhea.

Territorial aggression in male bower-building cichlids Nyassachromis cf. microcephalus is disrupted by exposure to environmental concentrations of fluoxetine

This study shows that fluoxetine exposure reduces territorial aggression in male cichlid fish, suggesting environmental serotonin disruption affects behavior.

Tumor Spheroids Layered in an Imageable Cancer Environment (T-SLICE): a novel in vitro platform to study tumor biology

The paper introduces T-SLICE, a 3D tumor model that mimics tumor heterogeneity and hypoxic gradients, enabling more accurate in vitro testing of therapeutics.

Internal calibration for opportunistic computed tomography muscle density analysis

This study develops and validates an internal calibration method for accurate muscle density analysis from CT scans without requiring external phantoms.

Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

Convergent Gene Expression Patterns During Compatible Interactions Between Two Pseudomonas syringae Pathovars and a Common Host (Nicotiana benthamiana)

The paper compares gene expression in two Pseudomonas syringae pathovars and their host during infection, finding similar responses with some strain-specific differences.

Time-Dependent Increase in Susceptibility and Severity of Secondary Bacterial Infection during SARS-CoV-2 Infection

This study shows that SARS-CoV-2 infection increases susceptibility and severity of secondary bacterial infection in mice, with time-dependent effects on immune responses and lethality.

RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

This study shows that RK-33, a DDX3 inhibitor, reduces SARS-CoV-2 viral load across multiple variants in Calu-3 cells and downregulates SARS-CoV-2 genes and TMPRSS2 expression.

Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences

This study evaluates remote undergraduate research experiences during the pandemic, finding similar scientific integration outcomes to in-person programs but with differences based on prior experience.

In planta transcriptomics reveals conflicts between pattern-triggered immunity and the AlgU sigma factor regulon

The paper identifies the AlgU sigma factor regulon in planta and shows its overlap with PTI-regulated genes in Pseudomonas syringae pv. tomato DC3000.

The structural repertoire of Fusarium oxysporum f. sp. lycopersici effectors revealed by experimental and computational studies

This study identifies a new structural class of fungal effectors in Fusarium oxysporum f. sp. lycopersici using experimental and computational methods, revealing structural relationships and immune recognition mechanisms.

Discovering tumor-reactive T-cell receptors through single-cell sequencing of tumor-infiltrating lymphocytes

The paper uses single-cell sequencing of tumor-infiltrating lymphocytes to identify and validate novel tumor-reactive T-cell receptors in a mouse model.

Zinc finger antiviral protein (ZAP) activity in mammalian and avian hosts in CpG and UpA-mediated restriction of RNA viruses and investigation of ZAP-mediated shaping of host transcriptome compositions

This study investigates ZAP activity in mammals and birds, finding no evidence that ZAP shapes antiviral gene compositions or impacts virus genome dinucleotide frequencies.