Author

C. F. Maher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

C.-Y. Lim· 1 shared E. Y. Wu· 1 shared H. R. Shin· 1 shared M. Kukurugya· 1 shared O. B. Davis· 1 shared P. Ordonez· 1 shared R. M. Perera· 1 shared R. Zoncu· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCell Biology

C.-Y. Lim

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1 paper

Recent·Most cited

NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C

O. B. Davis, H. R. Shin, C.-Y. Lim, E. Y. Wu, M. Kukurugya, C. F. Maher, R. M. Perera, P. Ordonez, R. Zoncu

This study identifies mTORC1 hyperactivation as a downstream driver of lysosomal dysfunction in NPC, showing that its inhibition can restore proteolysis and mitigate mitochondrial dysfunction.

bioRxiv · Aug 2, 2020Cell Biology