Author

R. Zoncu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

H. R. Shin· 2 shared J. H. Hurley· 2 shared R. M. Perera· 2 shared A. L. Yokom· 1 shared A. Stahl· 1 shared C. A. Berdan· 1 shared C. F. Maher· 1 shared C.-Y. Lim· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

H. R. Shin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation

R. M. Jansen, R. Peruzzo, S. A. Fromm, A. L. Yokom, R. Zoncu, J. H. Hurley

The paper determines the cryo-EM structure of the active FLCN complex, revealing how it selectively regulates mTORC1 substrates TFEB and TFE3.

bioRxiv · Jun 28, 2022 · PreprintBiochemistry

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

S. Gupta, J. A. Yano, H. Htwe Htwe, H. R. Shin, Z. Cakir, T. Ituarte, K. W. Wen, G. E. Kim, R. Zoncu, D. W. Dawson, R. M. Perera

This study identifies Myoferlin as a lysosomal membrane integrity factor in pancreatic cancer, showing its role in lysosome health and tumor growth.

Nature Cell Biology · Mar 8, 2021Peer-reviewedCancer Biology

4 β-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor.

O. Moldavski, P.-J. H. Zushin, C. A. Berdan, R. J. van Eijkeren, X. Jiang, M. Qian, D. S. Ory, D. F. Covey, D. Nomura, A. Stahl, E. Weiss, R. Zoncu

This study identifies 4β-hydroxycholesterol as a pro-lipogenic factor that activates SREBP1c via LXR to promote de novo lipogenesis.

bioRxiv · Aug 20, 2020Biochemistry

NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C

O. B. Davis, H. R. Shin, C.-Y. Lim, E. Y. Wu, M. Kukurugya, C. F. Maher, R. M. Perera, P. Ordonez, R. Zoncu

This study identifies mTORC1 hyperactivation as a downstream driver of lysosomal dysfunction in NPC, showing that its inhibition can restore proteolysis and mitigate mitochondrial dysfunction.

bioRxiv · Aug 2, 2020Cell Biology

Structure of the lysosomal SCARF (L-SCARF) complex, an Arf GAP haploinsufficient in ALS and FTD

M.-Y. Su, R. Zoncu, J. H. Hurley

The paper determines the structure of the L-SCARF complex, showing it functions as an Arf GAP and explains its role in ALS and FTD.

bioRxiv · Apr 15, 2020Biochemistry