IL-15 promotes inflammatory Th17 cells in the intestine
J. L. Golob, G. Hou, A. Lee, H. Grasberger, E. Berinstein, M. E. Zaatari, V. Khaykin, J. Berinstein, C. Fry, J. Nemzek, N. Kamada, J. Y. Kao, S. Bishu
The paper shows IL-15 promotes inflammatory Th17 cells in the intestine by upregulating RORC via JAK1 in TRM, suggesting IL-15 as a potential therapeutic target for UC.
bioRxiv · Mar 11, 2023 · PreprintImmunology