A. Lee

NCOA4 initiates ferritinophagy by avidly binding GATE16 using two short linear interaction motifs

This paper identifies two short linear motifs in NCOA4 that bind GATE16 with high avidity, enabling ferritinophagy and revealing a mechanism for iron-dependent regulation of this process.

Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma

This study shows that combining FACT and BET inhibition disrupts oncogenic transcription and extends survival in Diffuse Midline Glioma models.

Have AI-Generated Texts from LLM Infiltrated the Realm of Scientific Writing? A Large-Scale Analysis of Preprint Platforms

This study analyzes AI-generated text infiltration in scientific preprints using LLM detectors, finding widespread use across domains and positive impacts on citation numbers.

Inflammation induced Th17 cells synergize with the inflammation-trained microbiota to mediate host-resiliency against intestinal injury

The paper shows that transient inflammation generates protective Th17 cells that work with trained microbiota to protect against intestinal injury.

Misspellings or miscellings- non-verifiable cell lines in cancer research publications

The paper identifies non-verifiable human cell lines in cancer research publications, finding 235 papers referring to 7 cell lines as independent entities despite lacking proper documentation.

Identification of early-stage liver fibrosis by modifications in the interstitial space diffusive microenvironment using fluorescent single-walled carbon nanotubes

This study uses fluorescent single-walled carbon nanotubes to detect early-stage liver fibrosis by analyzing changes in the interstitial space's diffusive properties.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

MFSD7c functions as a transporter of choline at the blood-brain barrier

This study identifies MFSD7c as a choline transporter at the blood-brain barrier and links its dysfunction to Fowler syndrome.

Early life drought predicts components of adult body size in wild female baboons

This study finds that early-life drought in wild female baboons predicts shorter limbs but not torso length, with moderate heritability for body size measures.

Integrated Organ Immunity: Antigen-specific CD4-T cell-derived IFN-γ induced by BCG imprints prolonged lung innate resistance against respiratory viruses

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome

nELISA enables high-throughput, high-plex protein profiling of the inflammatory secretome, revealing 447 significant cytokine responses across multiple donors and conditions.

FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in-vitro toxicology and pharmacology

This paper develops FRESH 3D bioprinted cardiac tissues to improve in vitro pharmacology and toxicology screening by mimicking native-like physiological responses to adrenergic agonists.

IL-15 promotes inflammatory Th17 cells in the intestine

The paper shows IL-15 promotes inflammatory Th17 cells in the intestine by upregulating RORC via JAK1 in TRM, suggesting IL-15 as a potential therapeutic target for UC.

Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY

The paper identifies a core genome of nucleus-forming bacteriophages and characterizes the replication mechanism of Erwinia phage RAY.

Texture-Based Image Analysis For the Assessment of Soybeans

This paper applies texture-based image analysis to assess visual damage indicators in soybeans, aiming to improve grading efficiency and consistency.

Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis

This study identifies MERTK+ macrophages and fibroblasts involved in resolving fibrosis in frozen shoulder using single-cell analysis and suggests therapeutic strategies to enhance their interaction.

Cell-Sized Lipid Vesicles as Artificial Antigen-Presenting Cells for Antigen-Specific T Cell Activation

This study demonstrates artificial antigen-presenting cells (aAPCs) that activate T cells efficiently, showing significant increases in IFN-gamma secretion and T cell expansion without additional stimulants.

ATGL is differentially required for adipocyte FABP4 secretion in vivo and ex vivo

This study shows that ATGL is not required for lipolysis-stimulated FABP4 secretion from adipocytes, which can occur via sympathetic signaling.

Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion

This study identifies endothelial cells as the main source of baseline circulating FABP4 and shows they are required for lipolysis-driven insulin secretion.

PTH regulates osteogenesis and suppresses adipogenesis through Zfp 467 in a feed-forward, cyclic AMP-dependent manner

This study shows that PTH regulates bone formation by suppressing Zfp467 through cyclic AMP/PKA pathway, enhancing Pth1r transcription and osteogenesis.

Modelling the gastrointestinal carriage of Klebsiella pneumoniae infections.

This paper develops a murine model of Klebsiella pneumoniae gastrointestinal colonisation without tissue dissemination, identifying capsule polysaccharide and type VI secretion system roles in colonisation.

The promiscuous development of an unconventional Qa1b-restricted T cell population

The paper identifies a CD8 T cell population, QFL T cells, restricted to MHC-E that develops independently of classical MHC I and requires Qa1b for agonist selection and functionality.

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self

This study shows that MCMV downregulates ERAAP, leading to self-peptide presentation and an unconventional T cell response that reduces viral load.

MAIT cells have a negative impact on glioblastoma

The paper identifies MAIT cells as immunosuppressive in glioblastoma, correlating their presence with poor patient survival and immune suppressive gene upregulation.

Dynamic allostery in substrate binding by human thymidylate synthase

This study investigates the mechanism of substrate binding cooperativity in human thymidylate synthase using NMR experiments, revealing that rigidification and N-terminal interactions drive entropically-driven cooperativity.

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

The paper integrates transcriptional data from 13 vaccines to identify a time-adjusted signature predicting antibody responses across different vaccines.

Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing

The paper identifies a mechanism by which cholinergic calcium signals in colonic stem cell niches trigger MUC2 secretion and luminal flushing.

Near-infrared carbon nanotube tracking reveals the nanoscale extracellular space around synapses

The paper uses carbon nanotubes and microscopy to study the nanoscale extracellular space around synapses and finds it changes with neuronal activity.

A Novel Propidium Monoazide-Based PCR Assay Can Measure Viable Uropathogenic E. coli in Vitro and in Vivo

This paper develops a PMA-based PCR assay to detect viable uropathogenic E. coli in urine, showing it can identify live bacteria even after antibiotic treatment.