TFIIH kinase CDK7 antagonizes phenotype switching and emergence of drug tolerance in melanoma
P. Berico, m. cigrang, C. Braun, G. Davidson, j. Sandoz, S. Legras, F. peyresaubes, C. G. Robles, j.-m. egly, e. compe, I. Davidson, F. Coin
The paper shows CDK7 inhibition causes melanoma cells to switch from a melanocytic to mesenchymal phenotype and develop drug tolerance through a GATA6-regulated gene program.
bioRxiv · Sep 24, 2020 · PreprintCell Biology