G. Davidson

Novel synthetic ecteinascidins exhibit potent anti-melanoma activity by suppressing super-enhancer-driven oncogenic transcription

This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.

Super-enhancer driven expression of BAHCC1 promotes melanomacell proliferation and genome stability

The paper identifies BAHCC1 as a super-enhancer-driven gene in melanoma that promotes proliferation and genome stability, showing its potential as a therapeutic target.

Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model

The paper assesses WNT-3A binding affinity to endogenous versus overexpressed FZD7 in colorectal cancer cells and finds lower affinity with higher receptor concentrations.

Designing β-hairpin peptide macrocycles for antibiotic potential

The paper designs and screens a synthetic macrocyclic β-hairpin peptide library for antibiotic potential, identifying active peptides with unique structural and charge features.

Integrative genomics uncover mechanisms of renal medullary carcinoma transformation, microenvironment landscape and therapeutic vulnerabilities.

This study uses single-cell and multi-region sequencing to define RMC transformation, identify cell states, and uncover therapeutic vulnerabilities through transcriptional changes and microenvironment interactions.

Inhibitory control performance is repeatable across years and contexts in a wild bird population

The paper tests inhibitory control in wild birds using a modified detour task and finds performance is repeatable across time and contexts, suggesting the task measures genuine cognitive differences.

No reproductive benefits of dear enemy recognition in a territorial songbird

The paper tests if dear enemy recognition affects reproductive success in great tits, finding no benefits or costs associated with the behavior.

Genomic Evidence of Environmental and Resident Salmonella Senftenberg and Montevideo Contamination in the Pistachio Supply-chain

This study analyzes Salmonella contamination in pistachios using genomic data to identify persistent strains and their adaptation mechanisms.

TFIIH kinase CDK7 antagonizes phenotype switching and emergence of drug tolerance in melanoma

The paper shows CDK7 inhibition causes melanoma cells to switch from a melanocytic to mesenchymal phenotype and develop drug tolerance through a GATA6-regulated gene program.

Diet induces parallel changes to host gut microbiota and problem solving performance in a wild bird.

The study shows that diet affects gut microbiota diversity and problem-solving performance in wild birds, suggesting a link between microbiome changes and behavioral plasticity.

The TFIID subunit Taf4 is required for pancreatic beta cell function and identity.

This study shows that Taf4 inactivation in pancreatic beta cells causes functional defects and chromatin remodeling, leading to cell identity changes and trans-differentiation into alpha-like cells.

Citrullination of pyruvate kinase by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.

The paper shows that CHD4 regulates PADI1 and PADI3 to citrullinate PKM2, altering its activity and promoting glycolysis and cancer cell proliferation.