I. Davidson

Novel synthetic ecteinascidins exhibit potent anti-melanoma activity by suppressing super-enhancer-driven oncogenic transcription

This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.

Super-enhancer driven expression of BAHCC1 promotes melanomacell proliferation and genome stability

The paper identifies BAHCC1 as a super-enhancer-driven gene in melanoma that promotes proliferation and genome stability, showing its potential as a therapeutic target.

The E-cadherin-ESR1-GRPR axis defines a sex-specific metastatic pathway in melanoma

This study identifies an E-cadherin-ER-GRPR axis that drives sex-specific melanoma metastasis and shows GRPR inhibition reduces metastasis in vivo.

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks

The paper identifies super-enhancer networks regulating bladder cancer subtypes through transcription factors, showing their role in cell identity and inflammatory response suppression.

Integrative genomics uncover mechanisms of renal medullary carcinoma transformation, microenvironment landscape and therapeutic vulnerabilities.

This study uses single-cell and multi-region sequencing to define RMC transformation, identify cell states, and uncover therapeutic vulnerabilities through transcriptional changes and microenvironment interactions.

BRN2 is a non-canonical melanoma tumor-suppressor

This study identifies BRN2 as a non-canonical tumor suppressor in melanoma, showing its role in initiation and progression through PTEN regulation and PI3K signaling.

TFIIH kinase CDK7 antagonizes phenotype switching and emergence of drug tolerance in melanoma

The paper shows CDK7 inhibition causes melanoma cells to switch from a melanocytic to mesenchymal phenotype and develop drug tolerance through a GATA6-regulated gene program.

The TFIID subunit Taf4 is required for pancreatic beta cell function and identity.

This study shows that Taf4 inactivation in pancreatic beta cells causes functional defects and chromatin remodeling, leading to cell identity changes and trans-differentiation into alpha-like cells.

Citrullination of pyruvate kinase by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.

The paper shows that CHD4 regulates PADI1 and PADI3 to citrullinate PKM2, altering its activity and promoting glycolysis and cancer cell proliferation.