Glutamine Synthetase-1 induces autophagy-lysosomal degradation of huntingtin aggregates and ameliorates animal motility in a Drosophila model for Huntington’s disease
L. Vernizzi, C. Paiardi, G. Licata, T. Vitali, S. Santarelli, M. Raneli, V. Manelli, M. Rizzetto, M. Gioria, M. E. Pasini, D. Grifoni, M. A. Vanoni, C. Gellera, F. Taroni, P. Bellosta
This study shows that GS1 expression in Drosophila neurons reduces huntingtin aggregates and improves motility in a Huntington’s disease model by enhancing autophagy and inhibiting TOR signaling.
bioRxiv · Apr 30, 2019Cell Biology