Cell BiologybioRxiv
Glutamine Synthetase-1 induces autophagy-lysosomal degradation of huntingtin aggregates and ameliorates animal motility in a Drosophila model for Huntington’s disease
L. Vernizzi, C. Paiardi, G. Licata…·P. Bellosta
This study shows that GS1 expression in Drosophila neurons reduces huntingtin aggregates and improves motility in a Huntington’s disease model by enhancing autophagy and inhibiting TOR signaling.
DOI 10.3390/cells9010196