The immunomodulatory effect of IrSPI, a tick salivary gland serine protease inhibitor involved in Ixodes ricinus tick feeding
A. A. Blisnick, L. Simo, C. Grillon, F. Fasani, S. Brule, B. Le Bonniec, E. Prina, M. Marsot, A. Relmy, S. Blaise-Boisseau, J. Richardson, S. I. Bonnet
This paper identifies IrSPI, a tick salivary serine protease inhibitor, and shows it modulates the host immune response by inhibiting CD4+ T cell proliferation and altering cytokine secretion.
bioRxiv · Jul 17, 2019Animal Behavior & Cognition