E. Prina

MAPPING CHANGES OF MIRNA-MRNA NETWORKS IN LEISHMANIA-INFECTED MACROPHAGES PREDICTS REGULATORY MIRNA-TF LOOPS AS NOVEL TARGETS OF PARASITE IMMUNE SUBVERSION

Inhibition of the macrophage demethylase LSD1 reverses Leishmania amazonensis-induced transcriptomic changes and causes a decrease in parasite load

This study shows that inhibiting LSD1 in macrophages reduces Leishmania parasite load and reverses infection-induced transcriptomic changes.

Leishmania amazonensis controls macrophage-regulated cell death to establish chronic infection in vitro and in vivo

This study shows Leishmania amazonensis suppresses macrophage-regulated cell death pathways to promote chronic infection in vitro and in vivo.

The m6A reader IGF2BP2 directs immune-metabolic reprogramming in Leishmania amazonensis-infected macrophages

This study identifies IGF2BP2 as an m6A reader that stabilizes glycolytic transcripts in Leishmania-infected macrophages, promoting HIF-1-independent glycolysis and immune-metabolic reprogramming.

Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis

The paper measures cytoplasmic and nuclear volumes in human cells and finds cytoplasm grows exponentially while nucleus grows linearly, showing cytoskeletal forces influence nuclear import and volumetric coupling via osmosis.

Inkjet based 3D Printing of bespoke medical devices that resist bacterial biofilm formation

This paper develops 3D printing inks that resist bacterial biofilm formation and demonstrate their use in a finger prosthetic to prevent infection.

Dynamic High-Content Imaging Reveals Surface Exposure Of Virulent Leishmania Amastigotes In Infected Macrophages Undergoing Pyroptosis

This study shows that Leishmania-infected macrophages undergo pyroptosis, exposing amastigotes to the extracellular environment, which may aid parasite spread.

The immunomodulatory effect of IrSPI, a tick salivary gland serine protease inhibitor involved in Ixodes ricinus tick feeding

This paper identifies IrSPI, a tick salivary serine protease inhibitor, and shows it modulates the host immune response by inhibiting CD4+ T cell proliferation and altering cytokine secretion.

Leishmania targets the macrophage epigenome and dampens the NF-κB/NLRP3- mediated inflammatory response

This study shows Leishmania amazonensis modulates macrophage epigenetics to suppress NF-κB and NLRP3 inflammasome activation, aiding parasite survival.

Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche

The paper shows that precise 3D printed geometric structures influence stem cell differentiation without exogenous signaling molecules.