Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation
E. Abramson, C. Hardman, A. Shimizu, S. Hwang, L. D. Hester, S. H. Snyder, P. A. Wender, P. M. Kim, M. D. Kornberg
The paper shows that bryologs, synthetic analogs of bryostatin-1, reduce neuroinflammation by targeting PKC in innate immune cells, suggesting their potential as therapeutic agents for neuroinflammatory diseases.
bioRxiv · Sep 12, 2020Immunology