ImmunologybioRxiv
Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation
E. Abramson, C. Hardman, A. Shimizu…·M. D. Kornberg
The paper shows that bryologs, synthetic analogs of bryostatin-1, reduce neuroinflammation by targeting PKC in innate immune cells, suggesting their potential as therapeutic agents for neuroinflammatory diseases.
DOI 10.1016/j.chembiol.2020.12.015