Viral infection overcomes ineffectiveness of anti-tumoral CD8+ T cell mediated cytotoxicity
F. Zhou, J. Kardash, H. Bhat, V. Duhan, S. Friedrich, J. Bezgovsek, H. Kalkavan, M. Bergerhausen, M. Schiller, Y. Machlah, T. Brandenburg, C. Hardt, M. Krolik, L. Flatz, P. Lang, K. Lang
This study shows that viral infection can restore MHC-I expression and enhance T cell function, leading to tumor regression in a mouse melanoma model.
bioRxiv · Mar 27, 2019 · PreprintImmunology