TAPBPR mediates peptide dissociation from MHC class I using a leucine lever
F. T. Ilca, A. Neerincx, C. Hermann, A. Marcu, S. Stevanovic, J. E. Deane, L. H. Boyle
The paper identifies a leucine in the K22-D35 loop of TAPBPR that facilitates peptide dissociation from MHC I, revealing distinct mechanisms for peptide editing based on the C-terminal residue in the F pocket.
bioRxiv · Nov 5, 2018Immunology