J. E. Deane

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

The structure of a Plasmodium vivax Tryptophan Rich Antigen suggests a lipid binding function for a pan-Plasmodium multi-gene family

The paper determines the structure of a Plasmodium vivax TRAg and shows it binds lipids, suggesting a role in membrane remodeling during red blood cell invasion.

Attenuation hotspots in neurotropic human astroviruses

This study identifies attenuation hotspots in neurotropic human astroviruses by analyzing dispensable regions in the capsid-coding region and confirms their role in neuronal attenuation using recombinant viruses.

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

This study compares the structural features of PTPRK and PTPRM extracellular domains to identify determinants of homophilic adhesion, finding that shape complementarity and limited sequence differences drive specificity.

Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

This paper shows HSV-1 protein pUL21 activates CERT to increase ceramide to sphingomyelin conversion, but does not affect virus replication or spread.

The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds

This paper reports the crystal structure of vaccinia virus protein E2 and demonstrates that AlphaFold2 accurately predicts its structure despite its novelty and lack of sequence homology.

A tetrameric assembly of saposin A: increasing structural diversity in lipid transfer proteins

The paper reports the crystal structure of a tetrameric assembly of murine saposin A, revealing structural diversity in lipid transfer proteins.

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

This study identifies HIV-1 Vif amino acid polymorphisms that regulate PP2A antagonism and demonstrate that this function causes G2/M cell cycle arrest independently of APOBEC3 proteins.

The receptor PTPRU is a redox sensitive pseudophosphatase

This paper shows that PTPRU is a pseudophosphatase with no catalytic activity, functioning instead by competing with active phosphatases for substrate binding.

The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading

This study investigates whether Saposin B directly binds CD1d for lipid antigen loading and finds no direct interaction.

TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

The paper identifies a leucine in the K22-D35 loop of TAPBPR that facilitates peptide dissociation from MHC I, revealing distinct mechanisms for peptide editing based on the C-terminal residue in the F pocket.