Ultrasound-mediated blood-brain barrier disruption improves anti-pyroglutamate3 Aβ antibody efficacy and enhances phagocyte infiltration into brain in aged Alzheimer's disease-like mice
Q. Shi, T. Sun, Y. Zhang, C. Power, C. Hoesch, S. Antonelli, M. K. Schroeder, B. J. Caldarone, N. Taudte, M. Schenk, S. Schilling, N. McDannold, C. A. Lemere
This paper shows that combining ultrasound with an antibody improves Aβ removal and memory in Alzheimer's mice without causing brain bleeding.
bioRxiv · Jan 15, 2021 · PreprintBioengineering