Combining small-molecule bioconjugation and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to expose allostery: the case of human cytochrome P450 3A4
J. Ducharme, C. J. Thibodeaux, K. Auclair
The paper combines bioconjugation and HDX-MS to study allostery in CYP3A4, identifying key regions involved in activation.
bioRxiv · Jun 9, 2020Biochemistry