Author

J. Ducharme

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

K. Auclair· 2 shared C. J. Thibodeaux· 1 shared C. Thibodeaux· 1 shared F. H. Arnold· 1 shared F.-Z. Li· 1 shared I. F. Sevrioukova· 1 shared J. Yang· 1 shared K. E. Johnston· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

K. Auclair

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3 papers

Recent·Most cited

DeCOIL: Optimization of Degenerate Codon Libraries for Machine Learning-Assisted Protein Engineering

J. Yang, J. Ducharme, K. E. Johnston, F.-Z. Li, Y. Yue, F. H. Arnold

DeCOIL optimizes degenerate codon libraries for ML-assisted protein engineering to generate diverse and high-fitness protein variants.

bioRxiv · May 11, 2023Bioengineering

Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductase

J. Ducharme, I. F. Sevrioukova, C. Thibodeaux, K. Auclair

This study uses HDX-MS to show that CYP3A4 rigidifies upon binding substrates or CPR, affecting conformational dynamics and suggesting allostery mechanisms.

bioRxiv · Mar 9, 2021Biochemistry

Combining small-molecule bioconjugation and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to expose allostery: the case of human cytochrome P450 3A4

J. Ducharme, C. J. Thibodeaux, K. Auclair

The paper combines bioconjugation and HDX-MS to study allostery in CYP3A4, identifying key regions involved in activation.

bioRxiv · Jun 9, 2020Biochemistry