SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation
M. D. Moore, E. Johnson, C. Jacklin, S. Johnson, O. Green, W. S. James
This study shows that SAMHD1 knockout affects nucleoside analogue sensitivity, deoxyguanosine toxicity, and inflammation in macrophages, linking it to Acardi-Goutieres Syndrome and cancer therapies.
bioRxiv · Aug 25, 2022 · PreprintPharmacology & Toxicology