E. Johnson

Condensates of synaptic vesicles and synapsin are molecular beacons for actin sequestering and polymerization

The paper investigates how synapsin-SV condensates organize presynaptic actin through LLPS, revealing their role in SV clustering and actin polymerization in lamprey and mammalian synapses.

Nanogap Solid-State Single-Molecule Detection at Mars, Europa, and Microgravity Conditions

This paper develops a nanogap solid-state system for single-molecule detection under space-relevant conditions and validates its performance in microgravity and reduced gravity environments.

The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function

This study identifies BLTP2 as a pro-survival protein that regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function, linking it to cancer aggressiveness.

Expanding the ligandable proteome by paralog hopping with covalent probes

The paper uses covalent probes and paralog hopping to identify ligandable pockets in proteins lacking cysteines, demonstrating a method to expand the ligandable proteome.

Analysis of the influence of peptidoglycan turnover and recycling on host-pathogen interaction in the Gram-positive pathogen Staphylococcus aureus

This study investigates the role of peptidoglycan turnover and recycling in S. aureus host-pathogen interaction, showing that impaired recycling affects virulence and immune activation in Drosophila.

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation

This study shows that SAMHD1 knockout affects nucleoside analogue sensitivity, deoxyguanosine toxicity, and inflammation in macrophages, linking it to Acardi-Goutieres Syndrome and cancer therapies.

C4 Grasses Employ Distinct Strategies to Acclimate Rubisco Activase to Heat Stress

This study investigates how different C4 grasses regulate rubisco activase under heat stress, revealing species-specific adaptations in isoform abundance and biochemical regulation.

Landscape drives zoonotic malaria prevalence in non-human primates

The paper analyzes P. knowlesi prevalence in non-human primates across Southeast Asia, finding links between habitat fragmentation and infection rates, which may influence human malaria risk.

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

This study evaluates how compound interventions and genetic background affect healthspan and lifespan in C. elegans under stress conditions.

Genetic integration of behavioural and endocrine components of the stress response

This study shows that acute stress response traits in Trinidadian guppies are heritable and genetically integrated, suggesting potential for artificial selection to improve health and welfare in captive populations.

Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes

This study evaluates the lifespan and health effects of five compounds in Caenorhabditis nematodes, finding species- and strain-specific responses, assay-dependent outcomes, and uncoupling of lifespan and health effects.

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

High-throughput imaging of Caenorhabditis elegans aging using collective activity monitoring

The paper introduces WormCamp, a high-throughput system for aging research in C. elegans, showing it can estimate lifespan and healthspan through collective activity monitoring.

Epigenetic Remodeling by Vitamin C Potentiates the Differentiation of Mouse and Human Plasma Cells

This study shows vitamin C enhances plasma cell differentiation in mouse and human B cells by epigenetic remodeling via TET enzymes and STAT3-dependent mechanisms.

Dual transcriptional analysis of Peronospora belbahrii and Ocimum basilicum in susceptible interactions

The paper analyzes transcriptomes of Peronospora belbahrii and Ocimum basilicum during infection, identifying differentially expressed genes and pathways involved in defense and pathogen growth.

Qualification of ELISA and neutralization methodologies to measure SARS-CoV-2 humoral immunity using human clinical samples

This paper qualifies ELISA and neutralization assays to measure SARS-CoV-2 humoral immunity using clinical samples, evaluating antibody titers and functional neutralization capacity.

Reduced-Order Modeling and the Physics Governing Flapping Wing Fluid-Structure Interaction

The paper develops a reduced-order model for flapping wing fluid-structure interaction, showing it predicts wingtip deflection much faster than high-fidelity models while maintaining accuracy.

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

Inositol lipid synthesis is widespread in host-associated Bacteroidetes

This study identifies two pathways for inositol lipid synthesis in host-associated Bacteroidetes, showing their prevalence and potential role in host interactions.

Asbestos accelerates disease onset in a genetic model of Malignant Pleural Mesothelioma

This study shows asbestos accelerates mesothelioma onset and increases tumor burden in a genetic mouse model, with increased macrophage infiltration, but macrophage suppression did not improve survival.

The virulence of the Cryptococcus neoformans VNIa-5 lineage is highly plastic and associated with isolate background.

The study shows that the virulence of the Cryptococcus neoformans VNIa-5 lineage varies based on isolate source and can be induced through secreted proteins in extracellular vesicles.

Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

The paper develops mineralized collagen-amnion scaffolds that enhance osteogenesis in inflammatory conditions using porcine adipose-derived stem cells.

Glutamine deprivation regulates the origin and function of cancer cell exosomes

This study shows that glutamine deprivation increases exosome release from cancer cells, which promote tumor growth and blood vessel networks through Rab11a-dependent mechanisms.

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

A large close relative of C. elegans is slow-developing but not long-lived

This study compares developmental and life history traits between C. inopinata and C. elegans, finding slower development but similar lifespan in C. inopinata.

The role of AP-1 in self-sufficient proliferation and migration of cancer cells and its potential impact on an autocrine/paracrine loop.

This study investigates the role of AP-1 family members in cancer cell proliferation and migration under serum starvation, identifying an autocrine/paracrine loop involving Fra-1.

Drosophila PLP forms centriolar-clouds that promote centriole stability, cohesion and MT nucleation

This study investigates the role of Drosophila PLP in centriole structure and function, identifying its role in forming pericentriolar clouds that support centriole stability, cohesion, and microtubule nucleation.

Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses

This study examines the effect of seasonal influenza vaccination on intrahost diversity of H3N2 viruses using whole genome sequencing and finds minimal impact.